Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease

The small heat shock protein HSPB1 (Hsp27) is an ubiquitously expressed molecular chaperone able to regulate various cellular functions like actin dynamics, oxidative stress regulation and anti-apoptosis. So far disease causing mutations in HSPB1 have been associated with neurodegenerative diseases...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Geuens, Thomas, De Winter, Vicky, Rajan, Nicholas, Achsel, Tilmann, Mateiu, Ligia, Almeida-Souza, Leonardo, Asselbergh, Bob, Bouhy, Delphine, Auer-Grumbach, Michaela, Bagni, Claudia, Timmerman, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225548/
https://ncbi.nlm.nih.gov/pubmed/28077174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0407-3
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