Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease

The small heat shock protein HSPB1 (Hsp27) is an ubiquitously expressed molecular chaperone able to regulate various cellular functions like actin dynamics, oxidative stress regulation and anti-apoptosis. So far disease causing mutations in HSPB1 have been associated with neurodegenerative diseases...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Neuropathol Commun
Prif Awduron: Geuens, Thomas, De Winter, Vicky, Rajan, Nicholas, Achsel, Tilmann, Mateiu, Ligia, Almeida-Souza, Leonardo, Asselbergh, Bob, Bouhy, Delphine, Auer-Grumbach, Michaela, Bagni, Claudia, Timmerman, Vincent
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2017
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225548/
https://ncbi.nlm.nih.gov/pubmed/28077174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0407-3
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