Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1

Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disease caused by deficiency in fumarylacetoacetate hydrolase, the last enzyme in the tyrosine catabolic pathway. In this study, we investigated whether fumarylacetoacetate hydrolase deficient (FAH(−/−)) pigs, a novel large-animal model o...

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Bibliografiske detaljer
Udgivet i:Am J Pathol
Main Authors: Elgilani, Faysal, Mao, Shennen A., Glorioso, Jaime M., Yin, Meng, Iankov, Ianko D., Singh, Anisha, Amiot, Bruce, Rinaldo, Piero, Marler, Ronald J., Ehman, Richard L., Grompe, Markus, Lillegard, Joseph B., Hickey, Raymond D., Nyberg, Scott L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2017
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225308/
https://ncbi.nlm.nih.gov/pubmed/27855279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.09.013
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