Hypophysitis Secondary to Cytotoxic T-Lymphocyte–Associated Protein 4 Blockade: Insights into Pathogenesis from an Autopsy Series

Hypophysitis that develops in cancer patients treated with monoclonal antibodies blocking cytotoxic T-lymphocyte–associated protein 4 (CTLA-4; an inhibitory molecule classically expressed on T cells) is now reported at an incidence of approximately 10%. Its pathogenesis is unknown, in part because n...

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Vydáno v:Am J Pathol
Hlavní autoři: Caturegli, Patrizio, Di Dalmazi, Giulia, Lombardi, Martina, Grosso, Federica, Larman, H. Benjamin, Larman, Tatianna, Taverna, Giacomo, Cosottini, Mirco, Lupi, Isabella
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2016
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225294/
https://ncbi.nlm.nih.gov/pubmed/27750046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.08.020
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