Optogenetic stimulation of frontal D1 neurons compensates for impaired temporal control of action in dopamine-depleted mice

Disrupted mesocortical dopamine contributes to cognitive symptoms of Parkinson’s disease (PD). Past work has implicated medial frontal neurons expressing D1 dopamine receptors (D1DRs) in temporal processing. Here, we investigate if these neurons can compensate for behavioral deficits resulting from...

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Publicado en:Curr Biol
Main Authors: Kim, Young-Cho, Han, Sang-Woo, Alberico, Stephanie, Ruggiero, Rafael, De Corte, Benjamin, Chen, Kuan-Hua, Narayanan, Nandakumar S.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225083/
https://ncbi.nlm.nih.gov/pubmed/27989675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2016.11.029
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