A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease

OBJECTIVE: To test the hypothesis that chronic treatment of early-stage Huntington disease (HD) with high-dose coenzyme Q10 (CoQ) will slow the progressive functional decline of HD. METHODS: We performed a multicenter randomized, double-blind, placebo-controlled trial. Patients with early-stage HD (...

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Bibliografiske detaljer
Udgivet i:Neurology
Main Authors: McGarry, Andrew, McDermott, Michael, Kieburtz, Karl, de Blieck, Elisabeth A., Beal, Flint, Marder, Karen, Ross, Christopher, Shoulson, Ira, Gilbert, Peter, Mallonee, William M., Guttman, Mark, Wojcieszek, Joanne, Kumar, Rajeev, LeDoux, Mark S., Jenkins, Mary, Rosas, H. Diana, Nance, Martha, Biglan, Kevin, Como, Peter, Dubinsky, Richard M., Shannon, Kathleen M., O'Suilleabhain, Padraig, Chou, Kelvin, Walker, Francis, Martin, Wayne, Wheelock, Vicki L., McCusker, Elizabeth, Jankovic, Joseph, Singer, Carlos, Sanchez-Ramos, Juan, Scott, Burton, Suchowersky, Oksana, Factor, Stewart A., Higgins, Donald S., Molho, Eric, Revilla, Fredy, Caviness, John N., Friedman, Joseph H., Perlmutter, Joel S., Feigin, Andrew, Anderson, Karen, Rodriguez, Ramon, McFarland, Nikolaus R., Margolis, Russell L., Farbman, Eric S., Raymond, Lynn A., Suski, Valerie, Kostyk, Sandra, Colcher, Amy, Seeberger, Lauren, Epping, Eric, Esmail, Sherali, Diaz, Nancy, Fung, Wai Lun Alan, Diamond, Alan, Frank, Samuel, Hanna, Philip, Hermanowicz, Neal, Dure, Leon S., Cudkowicz, Merit
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224719/
https://ncbi.nlm.nih.gov/pubmed/27913695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003478
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