Susceptibility of Phytomonas serpens to calpain inhibitors in vitro: interference on the proliferation, ultrastructure, cysteine peptidase expression and interaction with the invertebrate host

A pleiotropic response to the calpain inhibitor MDL28170 was detected in the tomato parasite Phytomonas serpens. Ultrastructural studies revealed that MDL28170 caused mitochondrial swelling, shortening of flagellum and disruption of trans Golgi network. This effect was correlated to the inhibition i...

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Publicado en:Mem Inst Oswaldo Cruz
Main Authors: de Oliveira, Simone Santiago Carvalho, Gonçalves, Diego de Souza, Garcia-Gomes, Aline dos Santos, Gonçalves, Inês Correa, Seabra, Sergio Henrique, Menna-Barreto, Rubem Figueiredo, Lopes, Angela Hampshire de Carvalho Santos, D’Avila-Levy, Claudia Masini, dos Santos, André Luis Souza, Branquinha, Marta Helena
Formato: Artigo
Idioma:Inglês
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224352/
https://ncbi.nlm.nih.gov/pubmed/27925020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760160270
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