GPR4 Deficiency Alleviates Intestinal Inflammation in a Mouse Model of Acute Experimental Colitis

GPR4 is a proton-sensing G protein-coupled receptor that can be activated by extracellular acidosis. It has recently been demonstrated that activation of GPR4 by acidosis increases the expression of numerous inflammatory and stress response genes in vascular endothelial cells (ECs) and also augments...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Sanderlin, Edward J., Leffler, Nancy R., Lertpiriyapong, Kvin, Cai, Qi, Hong, Heng, Bakthavatchalu, Vasudevan, Fox, James G., Oswald, Joani Zary, Justus, Calvin R., Krewson, Elizabeth A., O’Rourke, Dorcas, Yang, Li V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222690/
https://ncbi.nlm.nih.gov/pubmed/27940273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2016.12.005
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