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Virtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic disease

In autosomal dominant polycystic kidney disease (ADPKD), cysts accumulate and progressively impair renal function. Mutations in PKD1 and PKD2 genes are causally linked to ADPKD, but how these mutations drive cell behaviors that underlie ADPKD pathogenesis is unknown. Human ADPKD cysts frequently exp...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Belmonte, Julio M., Clendenon, Sherry G., Oliveira, Guilherme M., Swat, Maciej H., Greene, Evan V., Jeyaraman, Srividhya, Glazier, James A., Bacallao, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221598/
https://ncbi.nlm.nih.gov/pubmed/27193300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-01-0059
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