Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain

OBJECTIVE: IP6 kinases (IP6Ks) regulate cell metabolism and survival. Mice with global (IP6K1-KO) or adipocyte-specific (AdKO) deletion of IP6K1 are protected from diet induced obesity (DIO) at ambient (23 °C) temperature. AdKO mice are lean primarily due to increased AMPK mediated thermogenic energ...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Zhu, Qingzhang, Ghoshal, Sarbani, Tyagi, Richa, Chakraborty, Anutosh
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220553/
https://ncbi.nlm.nih.gov/pubmed/28123939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.11.010
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