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Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities

CD97 belongs to the adhesion GPCR family characterized by a long ECD linked to the 7TM via a GPCR proteolytic site (GPS) and plays important roles in modulating cell migration and invasion. CD97 (EGF1-5) is a splicing variant of CD97 that recognizes a specific ligand chondroitin sulfate on cell memb...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Yang, Li-yun, Liu, Xiao-fang, Yang, Yang, Yang, Lin-lin, Liu, Kai-wen, Tang, Yu-bo, Zhang, Min, Tan, Min-jia, Cheng, Shan-mei, Xu, Ye-chun, Yang, Huai-yu, Liu, Zhi-jie, Song, Gao-jie, Huang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220547/
https://ncbi.nlm.nih.gov/pubmed/27641734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.89
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