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Therapeutic concentrations of varenicline in the presence of nicotine increase action potential firing in human adrenal chromaffin cells

Varenicline is a nicotinic acetylcholine receptor (nAChR) agonist used to treat nicotine addiction but a live debate persists concerning its mechanism of action in reducing nicotine consumption. Although initially reported as α4β2-selective, varenicline was subsequently shown to activate other nAChR...

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Bibliografiska uppgifter
I publikationen:J Neurochem
Huvudupphovsmän: Hone, Arik J., McIntosh, J. Michael, Rueda-Ruzafa, Lola, Passas, Juan, de Castro-Guerín, Cristina, Blázquez, Jesús, González-Enguita, Carmen, Albillos, Almudena
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220418/
https://ncbi.nlm.nih.gov/pubmed/27805736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13883
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