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Sparsely populated folding intermediates of the Fyn SH3 domain: Matching native-centric essential dynamics and experiment

A complete description of how a protein folds requires the characterization of intermediate conformations traversed during the folding transition. We have calculated dynamics trajectories of a simplified model of the Fyn SH3 domain with a native-centric potential energy function. Analysis of the res...

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Hlavní autoři: Ollerenshaw, Jason E., Kaya, Hüseyin, Chan, Hue Sun, Kay, Lewis E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC522025/
https://ncbi.nlm.nih.gov/pubmed/15469926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404436101
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