Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts

BACKGROUND: The Hedgehog (Hh) pathway is upregulated in cervical cancer and associated with poor outcome. We explored the effects of Hh pathway inhibition in combination with RTCT in a patient derived orthotopic cervical cancer xenograft model (OCICx). METHODS: 5E1, a monoclonal antibody for SHH, or...

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Vydáno v:Br J Cancer
Hlavní autoři: Chaudary, Naz, Pintilie, Melania, Hedley, David, Hill, Richard P, Milosevic, Michael, Mackay, Helen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220149/
https://ncbi.nlm.nih.gov/pubmed/27875522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.383
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