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Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice

BACKGROUND: There is inconclusive evidence about the role of sex as a risk factor for doxorubicin (DOX)-induced cardiotoxicity. Recent experimental studies have shown that adult female rats are protected against DOX-induced cardiotoxicity. However, the mechanisms of this sexual dimorphism are not fu...

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Bibliografske podrobnosti
izdano v:Biol Sex Differ
Main Authors: Grant, Marianne K. O., Seelig, Davis M., Sharkey, Leslie C., Zordoky, Beshay N.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5219702/
https://ncbi.nlm.nih.gov/pubmed/28078076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13293-016-0124-4
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