Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma

BACKGROUND: Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis. Targeting aerobic glycolysis presents a promising strategy for cancer therapy. This study inv...

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Li, Hui-Min, Yang, Jie-Gang, Liu, Zhuo-Jue, Wang, Wei-Ming, Yu, Zi-Li, Ren, Jian-Gang, Chen, Gang, Zhang, Wei, Jia, Jun
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5219669/
https://ncbi.nlm.nih.gov/pubmed/28061878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0481-1
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