IFN-γ enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation

We compared monocyte-derived dendritic cells and transforming growth factor-β1-induced Langerhans-like cells (LCs) for their capacity to cross-present exogenous NY-ESO-1 protein/antibody immune complexes to an NY-ESO-1-specific CD8(+) T cell clone. In contrast to dendritic cells, LCs were not able t...

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Autori principali: Matsuo, Mitsutoshi, Nagata, Yasuhiro, Sato, Eiichi, Atanackovic, Djordje, Valmori, Danila, Chen, Yao-Tseng, Ritter, Gerd, Mellman, Ira, Old, Lloyd J., Gnjatic, Sacha
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC521945/
https://ncbi.nlm.nih.gov/pubmed/15383663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405947101
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