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Bulk-solvent and hydration-shell fluctuations, similar to α- and β-fluctuations in glasses, control protein motions and functions

The concept that proteins exist in numerous different conformations or conformational substates, described by an energy landscape, is now accepted, but the dynamics is incompletely explored. We have previously shown that large-scale protein motions, such as the exit of a ligand from the protein inte...

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Detalhes bibliográficos
Main Authors: Fenimore, P. W., Frauenfelder, Hans, McMahon, B. H., Young, R. D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC521939/
https://ncbi.nlm.nih.gov/pubmed/15448207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405573101
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