The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

GPR139 is an orphan G protein-coupled receptor that is expressed primarily in the brain. Not much is known regarding the function of GPR139. Recently we have shown that GPR139 is activated by the amino acids l-tryptophan and l-phenylalanine (EC(50) values of 220 μM and 320 μM, respectively), as well...

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Detalhes bibliográficos
Publicado no:Neurochem Int
Main Authors: Nøhr, Anne Cathrine, Shehata, Mohamed A., Hauser, Alexander S., Isberg, Vignir, Mokrosinski, Jacek, Andersen, Kirsten B., Farooqi, I. Sadaf, Pedersen, Daniel Sejer, Gloriam, David E., Bräuner-Osborne, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Pergamon Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218887/
https://ncbi.nlm.nih.gov/pubmed/27916541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2016.11.012
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