Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1

The cyp125 gene of Rhodococcus jostii RHA1 was previously found to be highly upregulated during growth on cholesterol and the orthologue in Mycobacterium tuberculosis (rv3545c) has been implicated in pathogenesis. Here we show that cyp125 is essential for R. jostii RHA1 to grow on 3-hydroxysterols s...

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Bibliografske podrobnosti
izdano v:Mol Microbiol
Main Authors: Rosłoniec, Kamila Z., Wilbrink, Maarten H., Capyk, Jenna K., Mohn, William W., Ostendorf, Martin, van der Geize, Robert, Dijkhuizen, Lubbert, Eltis, Lindsay D.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218833/
https://ncbi.nlm.nih.gov/pubmed/19843222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2009.06915.x
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