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The Effector Domain Region of the Vibrio vulnificus MARTX Toxin Confers Biphasic Epithelial Barrier Disruption and Is Essential for Systemic Spread from the Intestine

Vibrio vulnificus causes highly lethal bacterial infections in which the Multifunctional Autoprocessing Repeats-in-Toxins (MARTX) toxin product of the rtxA1 gene is a key virulence factor. MARTX toxins are secreted proteins up to 5208 amino acids in size. Conserved MARTX N- and C-terminal repeat reg...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Gavin, Hannah E., Beubier, Nike T., Satchell, Karla J. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218395/
https://ncbi.nlm.nih.gov/pubmed/28060924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006119
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