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Cyclin-Dependent Kinase Activity Is Required at Early Times for Accurate Processing and Accumulation of the Human Cytomegalovirus UL122-123 and UL37 Immediate-Early Transcripts and at Later Times for Virus Production

Human cytomegalovirus (HCMV) infection leads to dysregulation of multiple cell cycle-regulatory proteins. In this study, we examined the effects of inhibition of cyclin-dependent kinase (cdk) activity on viral replication. With the drug Roscovitine, a specific inhibitor of cyclin-dependent kinases 1...

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Udgivet i:J Virol
Principais autores: Sanchez, Veronica, McElroy, Anita K., Yen, Judy, Tamrakar, Sama, Clark, Charles L., Schwartz, Rachel A., Spector, Deborah H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521808/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15452241/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.20.11219-11232.2004
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