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Human Immunodeficiency Virus Type 2 Gag Interacts Specifically with PRP4, a Serine-Threonine Kinase, and Inhibits Phosphorylation of Splicing Factor SF2

Using a yeast two-hybrid screen of a T-cell cDNA library to identify cellular proteins that bind to the human immunodeficiency virus type 2 (HIV-2) Gag polyprotein, we identified PRP4, a serine-threonine protein kinase. Specific interaction of PRP4 and HIV-2 Gag was confirmed in in vitro and in vivo...

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Detalhes bibliográficos
Main Authors: Bennett, Erin M., Lever, Andrew M. L., Allen, Jane F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC521795/
https://ncbi.nlm.nih.gov/pubmed/15452250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.20.11303-11312.2004
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