Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes

BACKGROUND: Triptolide (TP), an active constituent of Tripterygium wilfordii, possesses numerous pharmacological activities. However, its effects on cytochrome P450 enzymes (CYP450s) in rats remain unexplored. METHODS: In this study, the effects of triptolide on the six main CYP450 isoforms (1A2, 2C...

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Detalhes bibliográficos
Publicado no:BMC Complement Altern Med
Main Authors: Lu, Yan, Xie, Tong, Zhang, Yajie, Zhou, Fuqiong, Ruan, Jie, Zhu, Weina, Zhu, Huaxu, Feng, Zhe, Zhou, Xueping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217299/
https://ncbi.nlm.nih.gov/pubmed/28056947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12906-016-1504-3
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