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Weighted analysis of composite endpoints with simultaneous inference for flexible weight constraints

Composite endpoints are widely used as primary endpoints of randomized controlled trials across clinical disciplines. A common critique of the conventional analysis of composite endpoints is that all disease events are weighted equally, whereas their clinical relevance may differ substantially. We a...

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Detalhes bibliográficos
Publicado no:Stat Med
Main Authors: Duc, Anh Nguyen, Wolbers, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217097/
https://ncbi.nlm.nih.gov/pubmed/27782312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7147
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