Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine

Our goal is to develop a pediatric combination vaccine to protect the vulnerable infant population against human immunodeficiency virus type 1 (HIV-1) and tuberculosis (TB) infections. The vaccine consists of an auxotroph Mycobacterium tuberculosis strain that coexpresses HIV antigens. Utilizing an...

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Bibliographic Details
Published in:Clin Vaccine Immunol
Main Authors: Jensen, Kara, dela Pena-Ponce, Myra Grace, Piatak, Michael, Shoemaker, Rebecca, Oswald, Kelli, Jacobs, William R., Fennelly, Glenn, Lucero, Carissa, Mollan, Katie R., Hudgens, Michael G., Amedee, Angela, Kozlowski, Pamela A., Estes, Jacob D., Lifson, Jeffrey D., Van Rompay, Koen K. A., Larsen, Michelle, De Paris, Kristina
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216431/
https://ncbi.nlm.nih.gov/pubmed/27655885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00360-16
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