Cannabinoid CB(2) receptor ligand profiling reveals biased signalling and off-target activity

The cannabinoid CB(2) receptor (CB(2)R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB(2)R, their selectivity, molecular mode of action and pharmacokinetic properties...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Soethoudt, Marjolein, Grether, Uwe, Fingerle, Jürgen, Grim, Travis W., Fezza, Filomena, de Petrocellis, Luciano, Ullmer, Christoph, Rothenhäusler, Benno, Perret, Camille, van Gils, Noortje, Finlay, David, MacDonald, Christa, Chicca, Andrea, Gens, Marianela Dalghi, Stuart, Jordyn, de Vries, Henk, Mastrangelo, Nicolina, Xia, Lizi, Alachouzos, Georgios, Baggelaar, Marc P., Martella, Andrea, Mock, Elliot D., Deng, Hui, Heitman, Laura H., Connor, Mark, Di Marzo, Vincenzo, Gertsch, Jürg, Lichtman, Aron H., Maccarrone, Mauro, Pacher, Pal, Glass, Michelle, van der Stelt, Mario
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216056/
https://ncbi.nlm.nih.gov/pubmed/28045021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13958
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