Cannabinoid CB(2) receptor ligand profiling reveals biased signalling and off-target activity

The cannabinoid CB(2) receptor (CB(2)R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB(2)R, their selectivity, molecular mode of action and pharmacokinetic properties...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Soethoudt, Marjolein, Grether, Uwe, Fingerle, Jürgen, Grim, Travis W., Fezza, Filomena, de Petrocellis, Luciano, Ullmer, Christoph, Rothenhäusler, Benno, Perret, Camille, van Gils, Noortje, Finlay, David, MacDonald, Christa, Chicca, Andrea, Gens, Marianela Dalghi, Stuart, Jordyn, de Vries, Henk, Mastrangelo, Nicolina, Xia, Lizi, Alachouzos, Georgios, Baggelaar, Marc P., Martella, Andrea, Mock, Elliot D., Deng, Hui, Heitman, Laura H., Connor, Mark, Di Marzo, Vincenzo, Gertsch, Jürg, Lichtman, Aron H., Maccarrone, Mauro, Pacher, Pal, Glass, Michelle, van der Stelt, Mario
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216056/
https://ncbi.nlm.nih.gov/pubmed/28045021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13958
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