Cannabinoid CB(2) receptor ligand profiling reveals biased signalling and off-target activity

The cannabinoid CB(2) receptor (CB(2)R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB(2)R, their selectivity, molecular mode of action and pharmacokinetic properties...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Soethoudt, Marjolein, Grether, Uwe, Fingerle, Jürgen, Grim, Travis W., Fezza, Filomena, de Petrocellis, Luciano, Ullmer, Christoph, Rothenhäusler, Benno, Perret, Camille, van Gils, Noortje, Finlay, David, MacDonald, Christa, Chicca, Andrea, Gens, Marianela Dalghi, Stuart, Jordyn, de Vries, Henk, Mastrangelo, Nicolina, Xia, Lizi, Alachouzos, Georgios, Baggelaar, Marc P., Martella, Andrea, Mock, Elliot D., Deng, Hui, Heitman, Laura H., Connor, Mark, Di Marzo, Vincenzo, Gertsch, Jürg, Lichtman, Aron H., Maccarrone, Mauro, Pacher, Pal, Glass, Michelle, van der Stelt, Mario
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216056/
https://ncbi.nlm.nih.gov/pubmed/28045021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13958
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