Interplay Between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediate Castration Resistance

Androgen receptor splice variants (AR-Vs) are implicated in resistance of prostate cancer to androgen-directed therapies. When expressed alone in cells, some AR-Vs (e.g., AR-V7) localize primarily to the nucleus, whereas others (e.g., AR-V1, AR-V4, and AR-V6) localize mainly to the cytoplasm. Signif...

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Bibliographic Details
Published in:Mol Cancer Res
Main Authors: Zhan, Yang, Zhang, Guanyi, Wang, Xiaojie, Qi, Yanfeng, Bai, Shanshan, Li, Dongying, Ma, Tianfang, Sartor, Oliver, Flemington, Erik K., Zhang, Haitao, Lee, Peng, Dong, Yan
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215946/
https://ncbi.nlm.nih.gov/pubmed/27671337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0236
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