Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG), or high-grade brainstem glioma (BSG), is one of the major causes of brain tumor-related deaths in children. Its prognosis has remained poor despite numerous efforts to improve survival. Panobinostat, a histone deacetylase inhibitor, is a targeted...

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Veröffentlicht in:PLoS One
Hauptverfasser: Hennika, Tammy, Hu, Guo, Olaciregui, Nagore G., Barton, Kelly L., Ehteda, Anahid, Chitranjan, Arjanna, Chang, Cecilia, Gifford, Andrew J., Tsoli, Maria, Ziegler, David S., Carcaboso, Angel M., Becher, Oren J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215670/
https://ncbi.nlm.nih.gov/pubmed/28052119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169485
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