Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen‐activated protein kinase phosphatase‐1

Sirtuin 2 (Sirt2) is known to negatively regulate anoxia‐reoxygenation injury in myoblasts. Because protein levels of Sirt2 are increased in ischemia‐reperfusion (I/R)‐injured liver tissues, we examined whether Sirt2 is protective or detrimental against hepatic I/R injury. We overexpressed Sirt2 in...

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Vydáno v:Hepatology
Hlavní autoři: Wang, Jie, Koh, Hyoung‐Won, Zhou, Lu, Bae, Ui‐Jin, Lee, Hwa‐Suk, Bang, In Hyuk, Ka, Sun‐O, Oh, Seon‐Hee, Bae, Eun Ju, Park, Byung‐Hyun
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Liver Injury/Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215544/
https://ncbi.nlm.nih.gov/pubmed/27532371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28777
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