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Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia

Herpes simplex virus 1 (HSV-1) latency entails the repression of productive (“lytic”) gene expression. An attractive hypothesis to explain some of this repression involves inhibition of the expression of ICP0, a lytic gene activator, by a viral microRNA, miR-H2, which is completely complementary to...

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發表在:J Virol
Main Authors: Pan, Dongli, Pesola, Jean M., Li, Gang, McCarron, Seamus, Coen, Donald M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215319/
https://ncbi.nlm.nih.gov/pubmed/27847363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02001-16
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