Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti. Cre-Lox fate mapping shows this region gives rise to inner hai...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Basch, Martin L, Brown, Rogers M, Jen, Hsin-I, Semerci, Fatih, Depreux, Frederic, Edlund, Renée K, Zhang, Hongyuan, Norton, Christine R, Gridley, Thomas, Cole, Susan E, Doetzlhofer, Angelika, Maletic-Savatic, Mirjana, Segil, Neil, Groves, Andrew K
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215100/
https://ncbi.nlm.nih.gov/pubmed/27966429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19921
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