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Neuronal Cell Bodies Remotely Regulate Axonal Growth Response to Localized Netrin-1 Treatment via Second Messenger and DCC Dynamics

Netrin-1 modulates axonal growth direction and speed. Its best characterized receptor, Deleted in Colorectal Cancer (DCC), is localized to growth cones, but also observed in the cell bodies. We hypothesized that cell bodies sense Netrin-1 and contribute to axon growth rate modulation, mediated by th...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Blasiak, Agata, Kilinc, Devrim, Lee, Gil U.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214882/
https://ncbi.nlm.nih.gov/pubmed/28105005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00298
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