A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells

Functional intestines are composed of cell types from all 3 primary germ layers and are generated through a highly orchestrated and serial developmental process. Directed differentiation of human pluripotent stem cells (hPSCs) has been shown to yield gut-specific cell types; however, these structure...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Uchida, Hajime, Machida, Masakazu, Miura, Takumi, Kawasaki, Tomoyuki, Okazaki, Takuya, Sasaki, Kengo, Sakamoto, Seisuke, Ohuchi, Noriaki, Kasahara, Mureo, Umezawa, Akihiro, Akutsu, Hidenori
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
Subjects:
Technical Advance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214546/
https://ncbi.nlm.nih.gov/pubmed/28097227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86492
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