A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers

Approximately 50% of high-grade serous ovarian cancers (HGSOCs) have defects in genes involved in homologous recombination (HR) (i.e., BRCA1/2). Preclinical models to optimize therapeutic strategies for HR-deficient (HRD) HGSOC are lacking. We developed a preclinical platform for HRD HGSOCs that inc...

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Bibliografiska uppgifter
I publikationen:JCI Insight
Huvudupphovsmän: George, Erin, Kim, Hyoung, Krepler, Clemens, Wenz, Brandon, Makvandi, Mehran, Tanyi, Janos L., Brown, Eric, Zhang, Rugang, Brafford, Patricia, Jean, Stephanie, Mach, Robert H., Lu, Yiling, Mills, Gordon B., Herlyn, Meenhard, Morgan, Mark, Zhang, Xiaochen, Soslow, Robert, Drapkin, Ronny, Johnson, Neil, Zheng, Ying, Cotsarelis, George, Nathanson, Katherine L., Simpkins, Fiona
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214535/
https://ncbi.nlm.nih.gov/pubmed/28097235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89760
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