CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.

Toxin A from Clostridium difficile mediates acute inflammatory enterocolitis in experimental animals, while cholera toxin causes noninflammatory secretory diarrhea. The purpose of this study was to investigate whether an antagonist to the peptide substance P, a constituent of primary sensory neurons...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pothoulakis, C, Castagliuolo, I, LaMont, J T, Jaffer, A, O'Keane, J C, Snider, R M, Leeman, S E
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521430/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7508124/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.3.947
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