Phosphorylation impact on Spleen Tyrosine kinase conformation by Surface Enhanced Raman Spectroscopy

Spleen Tyrosine Kinase (Syk) plays a crucial role in immune cell signalling and its altered expression or activation are involved in several cancers. Syk activity relies on its phosphorylation status and its multiple phosphorylation sites predict several Syk conformations. In this report, we charact...

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Published in:Sci Rep
Main Authors: Cottat, Maximilien, Yasukuni, Ryohei, Homma, Yo, Lidgi-Guigui, Nathalie, Varin-Blank, Nadine, Lamy de la Chapelle, Marc, Le Roy, Christine
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214100/
https://ncbi.nlm.nih.gov/pubmed/28054556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39766
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