Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition

Branched-chain amino acids (BCAAs) are essential amino acids for mammals and play key roles in the regulation of protein metabolism. However, the effect of BCAA deficiency on protein metabolism in skeletal muscle in vivo remains unclear. Here we generated mice with lower BCAA concentrations by speci...

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Published in:Sci Rep
Main Authors: Ishikawa, Takuya, Kitaura, Yasuyuki, Kadota, Yoshihiro, Morishita, Yukako, Ota, Miki, Yamanaka, Fumiya, Xu, Minjun, Ikawa, Masahito, Inoue, Naokazu, Kawano, Fuminori, Nakai, Naoya, Murakami, Taro, Miura, Shinji, Hatazawa, Yukino, Kamei, Yasutomi, Shimomura, Yoshiharu
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209746/
https://ncbi.nlm.nih.gov/pubmed/28051178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39825
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