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Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5

Programmed cell death 5 (PDCD5) is believed to play a crucial role in p53 activation; however, the underlying mechanism of how PDCD5 function is regulated during apoptosis remains obscure. Here, we report that the serine/threonine phosphatase PPEF-1 interacts with and dephosphorylates PDCD5 at Ser-1...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Park, Soo-Yeon, Seo, Jaesung, Choi, Hyo-Kyoung, Oh, Hye-Jeong, Guk, Garam, Lee, Yoo-Hyun, Lee, Jeongmin, Jun, Woo Jin, Choi, Kyung-Chul, Yoon, Ho-Geun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209732/
https://ncbi.nlm.nih.gov/pubmed/28051100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39222
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