Double-Blind Controlled Randomized Trial of Cyclophosphamide versus Methylprednisolone in Secondary Progressive Multiple Sclerosis

BACKGROUND: Therapeutic options are limited in secondary progressive multiple sclerosis (SPMS). Open-label studies suggested efficacy of monthly IV cyclophosphamide (CPM) without induction for delaying progression but no randomized trial was conducted so far. OBJECTIVE: To compare CPM to methylpredn...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Brochet, Bruno, Deloire, Mathilde S. A., Perez, Paul, Loock, Timothé, Baschet, Louise, Debouverie, Marc, Pittion, Sophie, Ouallet, Jean-Christophe, Clavelou, Pierre, de Sèze, Jérôme, Collongues, Nicolas, Vermersch, Patrick, Zéphir, Hélène, Castelnovo, Giovanni, Labauge, Pierre, Lebrun, Christine, Cohen, Mikael, Ruet, Aurélie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207788/
https://ncbi.nlm.nih.gov/pubmed/28045953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168834
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