Co-Targeting IGF-1R and Autophagy Enhances the Effects of Cell Growth Suppression and Apoptosis Induced by the IGF-1R Inhibitor NVP-AEW541 in Triple-Negative Breast Cancer Cells

BACKGROUND: Triple-negative breast cancer (TNBC) is the most intractable type of breast cancer, and there is a lack of effective targeted therapy. Insulin-like growth factor-1 receptor (IGF-1R) is reportedly a potential target for TNBC treatment. However, satisfying treatment outcomes in breast canc...

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Udgivet i:PLoS One
Main Authors: Wu, Weibin, Ma, Jieyi, Shao, Nan, Shi, Yawei, Liu, Ruiming, Li, Wen, Lin, Yin, Wang, Shenming
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207513/
https://ncbi.nlm.nih.gov/pubmed/28046018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169229
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