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Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity

Shroom-mediated remodeling of the actomyosin cytoskeleton is a critical driver of cellular shape and tissue morphology that underlies the development of many tissues including the neural tube, eye, intestines, and vasculature. Shroom uses a conserved SD2 domain to direct the subcellular localization...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zalewski, Jenna K., Mo, Joshua H., Heber, Simone, Heroux, Annie, Gardner, Richard G., Hildebrand, Jeffrey D., VanDemark, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207239/
https://ncbi.nlm.nih.gov/pubmed/27758857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738559
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