Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D

VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that signal for growth of blood vessels and lymphatics....

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Davydova, Natalia, Harris, Nicole C., Roufail, Sally, Paquet-Fifield, Sophie, Ishaq, Musarat, Streltsov, Victor A., Williams, Steven P., Karnezis, Tara, Stacker, Steven A., Achen, Marc G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207153/
https://ncbi.nlm.nih.gov/pubmed/27852824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.736801
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