An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex

DNA double-strand break (DSB) repair by non-homologous end joining (NHEJ) in human cells is initiated by Ku heterodimer binding to a DSB, followed by recruitment of core NHEJ factors including DNA-dependent protein kinase catalytic subunit (DNA-PKcs), XRCC4-like factor (XLF), and XRCC4 (X4)-DNA liga...

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Vydáno v:J Biol Chem
Hlavní autoři: Hammel, Michal, Yu, Yaping, Radhakrishnan, Sarvan K., Chokshi, Chirayu, Tsai, Miaw-Sheue, Matsumoto, Yoshihiro, Kuzdovich, Monica, Remesh, Soumya G., Fang, Shujuan, Tomkinson, Alan E., Lees-Miller, Susan P., Tainer, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207133/
https://ncbi.nlm.nih.gov/pubmed/27875301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.751867
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