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Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine
In human urinary tract infections, host cells release the antimicrobial protein siderocalin (SCN; also known as lipocalin-2, neutrophil gelatinase-associated lipocalin, or 24p3) into the urinary tract. By binding to ferric catechol complexes, SCN can sequester iron, a growth-limiting nutrient for mo...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5207064/ https://ncbi.nlm.nih.gov/pubmed/27780864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.759183 |
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