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Increased burden of deleterious variants in essential genes in autism spectrum disorder

Autism spectrum disorder (ASD) is a heterogeneous, highly heritable neurodevelopmental syndrome characterized by impaired social interaction, communication, and repetitive behavior. It is estimated that hundreds of genes contribute to ASD. We asked if genes with a strong effect on survival and fitne...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Ji, Xiao, Kember, Rachel L., Brown, Christopher D., Bućan, Maja
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206557/
https://ncbi.nlm.nih.gov/pubmed/27956632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613195113
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