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Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration
O-GlcNAc glycosylation (or O-GlcNAcylation) is a dynamic, inducible posttranslational modification found on proteins associated with neurodegenerative diseases such as α-synuclein, amyloid precursor protein, and tau. Deletion of the O-GlcNAc transferase (ogt) gene responsible for the modification ca...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5206508/ https://ncbi.nlm.nih.gov/pubmed/27956640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606899113 |
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