Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1

The importance of actin dynamics in the activation of the inflammasome is becoming increasingly apparent. IL-1β, which is activated by the inflammasome, is known to be central to the pathogenesis of many monogenic autoinflammatory diseases. However, evidence from an autoinflammatory murine model ind...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Standing, Ariane S.I., Malinova, Dessislava, Hong, Ying, Record, Julien, Moulding, Dale, Blundell, Michael P., Nowak, Karolin, Jones, Hannah, Omoyinmi, Ebun, Gilmour, Kimberly C., Medlar, Alan, Stanescu, Horia, Kleta, Robert, Anderson, Glenn, Nanthapisal, Sira, Gomes, Sonia Melo, Klein, Nigel, Eleftheriou, Despina, Thrasher, Adrian J., Brogan, Paul A.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206503/
https://ncbi.nlm.nih.gov/pubmed/27994071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161228
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