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Collagen Substrate Stiffness Anisotropy Affects Cellular Elongation, Nuclear Shape and Stem Cell Fate towards Anisotropic Tissue Lineage

Rigidity of substrates plays an important role in stem cell fate. Studies were commonly carried out on isotropically stiff substrate or substrates with unidirectional stiffness gradients. However, many native tissues are anisotropically stiff and it is unknown whether controlled presentation of stif...

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Bibliographic Details
Published in:Adv Healthc Mater
Main Authors: Islam, Anowarul, Younesi, Mousa, Mbimba, Thomas, Akkus, Ozan
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203936/
https://ncbi.nlm.nih.gov/pubmed/27377355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201600284
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